Prediction of co-regulated genes

Goro Terai, Toshihisa Takagi, and Kenta Nakai, "Prediction of co-regulated genes in Bacillus subtilis based on the conserved upstream elements across three closely related species", submitted.

Ranka Geneb Positionc Sequenced Binding factore Speciesf Functional classificationg
#1
(pckA)
(metK)
ykrW
yusC
-246 : -183
-258 : -291
-105 : -159
-165 : -182
_CGGTTGCTGGGCTTCATAGGGC..
__GGTTGCTGGGCTTCATAGGGC..
..GGTTGCCGGGCTTCATCGGGC..
__GGTTGCCGGGCTTCATAG




S
H S
S
H
main glycolytic pathways
metabolism of amino acids and related molecules
specific pathways
transport/binding proteins and lipoproteins
#2
alaS
ileS
leuS
ilvB
tyrZ
tyrS
valS
proB
pheS
hisS
serS
glyQ
thrS
-113 : -97
-89 : -73
-150 : -135
-161 : -143
-77 : -62
-88 : -69
-98 : -80
-87 : -72
-106 : -89
-128 : -103
-88 : -73
-122 : -101
-91 : -71
______AGGGTGGTACCGCGAG-A
______AGGGTGGTACCGCGAGA
______AGGGTGGTACCGCGGG
______AGGGTGGTACCGCGGAAAG
______AGGGTGGTACCGCGTG
_TTAGTAGGGTGGTACCGCGA
__AAAAAAGGTGGTACCGCGA
______AAGGTGGTACCACGGA
__AATAAGGGTGGTACCGCG
__AACTAGGGTGGCACCACGGGT..
______AGGGTGGCAACGCGAG
GCAACTAGGGTGGAACCGCGGG
GAAAAAAGGGTGGAACCACGA













H S
H S
H S
H S
H
S
H S
H S
H
H S
H S
H
H S
aminoacyl-tRNA synthetases
aminoacyl-tRNA synthetases
aminoacyl-tRNA synthetases
metabolism of amino acids and related molecules
aminoacyl-tRNA synthetases
aminoacyl-tRNA synthetases
aminoacyl-tRNA synthetases
metabolism of amino acids and related molecules
aminoacyl-tRNA synthetases
aminoacyl-tRNA synthetases
aminoacyl-tRNA synthetases
aminoacyl-tRNA synthetases
aminoacyl-tRNA synthetases
#3
serS
leuS
alaS
glyQ
ileS
hisS
thrS
pheS
-71 : -58
-123 : -111
-95 : -83
-98 : -83
-68 : -56
-102 : -93
-55 : -45
-80 : -70
_GCTCTCGTCCCTTT
__CTCTCGTCCCTTT
AGCTCTCGTCCCT
AACTCTCGTCCCTATG
CTTTCTCGTCCCT
___TCTCGTCCCT
____CTCGTCCCTTT
_____TCGTCCCTTGT








H S
H S
H S
H
H S
H S
H S
H
aminoacyl-tRNA synthetases
aminoacyl-tRNA synthetases
aminoacyl-tRNA synthetases
aminoacyl-tRNA synthetases
aminoacyl-tRNA synthetases
aminoacyl-tRNA synthetases
aminoacyl-tRNA synthetases
aminoacyl-tRNA synthetases
#4
arsR
arsR
rsfA
-37 : -10
-98 : -75
-159 : -146
_ATACATCAAAAAAAATTGATTAA..
AATTAATCAAAATAAATTGATTTA
____TTTCAAAAAAAATC



H
H
H
regulation
regulation
Sporulation
#5
ykrW
ykrT
(yjcH)
(yjcI)
yitJ
metE
-101 : -78
-132 : -113
-245 : -261
-111 : -95
-137 : -118
-166 : -155
_AAGCACGGTGCTAATTCTTGCAGC
AAGGCACGGTGCTAATTCCA
_______GGTGCTAAATCCAGC-AA
_______GGTGCTAAATCCAGC-AA
_GACCAAGGTGCTAAATCCAG
______CGGTGCTAATTC






S
S
S
H S
S
H
specific pathways
none
none
metabolism of amino acids and related molecules
none
metabolism of amino acids and related molecules
#6
ctsR
clpE
dnaJ
clpE
clpE
-37 : -18
-159 : -143
-126 : -108
-90 : -76
-209 : -194
_GTCAAATATAGTCAAAGTCA
GGTCAAAGATAGTCAAA
_______GAAAGTCAAAGTCAGGCAT
____ACTAATAGTCAAAGA
____ACTATTAATCAAAGTT
CtsR
CtsR

CtsR
CtsR
H S
H
S
H
H
regulation
adaptation to atypical conditions
adaptation to atypical conditions
adaptation to atypical conditions
adaptation to atypical conditions
#7
citZ
rpoE
yqeG
pnbA
-215 : -190
-105 : -90
-179 : -172
-32 : -24
ATTATTGTTTATAATGAGAATAGGCT
_ATTTTGTTTATAATGA
_____TGTTTATA
______GTTTATAAT
SigA



H
H S
H S
H S
TCA cycle
elongation
none
antibiotic production
#8
spoIIAA
ywkC
abrB
-82 : -69
-71 : -61
-284 : -275
CCACTAGTTTTGTC
___CTTGTTTTGTC
____GAATTTTGTC
SinR


H S
H S
H S
sporulation
none
regulation
#9
spoIIQ
yjcI
yitJ
rpsJ
-30 : -5
-137 : -154
-159 : -169
-98 : -58
..AATG-TTGCTGAGGTGATGA
__GCCGGTTGCTGAGGTTTC
_____GGTTGCTGAAG
____AGGTTGCTGACACACC..




H S
H S
S
H
sporulation
metabolism of amino acids and related molecules
none
ribosomal proteins
#10
glyQ
hisS
ynaB
-68 : -47
-77 : -61
-36 : -17
GCATAGAGACGGGAGTTTTTTG
____AGGGGCGGGAGTTTTTT
AATGACTATAAAGAGTTTTT



H
H
H
aminoacyl-tRNA synthetases
aminoacyl-tRNA synthetases
none
#11
yitJ
(yjcH)
(yjcI)
ykrT
ykrW
metK
-105 : -88
-275 : -290
-76 : -63
-101 : -87
-72 : -59
-175 : -168
GCTTGGAAGATAAGAAGA
__TTGGAAGATAAGAAGA
_______AGATAAGAAGAAGC
T-CTGAGAGATAAGAG
_GCTGAGAGATAAGA
________GATAAGAG






S
S
H S
S
S
H S
none
none
metabolism of amino acids and related molecules
none
specific pathways
metabolism of amino acids and related molecules
#12
gapB
pckA
speD
-67 : -47
-60 : -46
-155 : -125
_TTAATGTGTTATACTAATTTT
__ATATATGTTATACTA
TTAAACACAGTATACTATTTTTC..



H
H S
H
main glycolytic pathways
main glycolytic pathways
metabolism of amino acids and related molecules
#13
(ydiL)
(groES)
hrcA
hrcA
-190 : -170
-7 : -27
-23 : -9
-32 : -46
CTAAAGAGTGCTAACACAATT
CTAAAGAGTGCTAACACAATT
_____GAGTGCTAACAGAGG
____CGAGTGCTAATTCTA

HrcA
HrcA
HrcA
H
H
H S
H S
none
protein folding
regulation, [the first gene of dnaK operon]
regulation, [the first gene of dnaK operon]
#14
pbuG
xpt
-188 : -153
-144 : -128
___AGTCTCTACCAAGCTACCGTA..
GCAAGTTTCTACCGGGC


H S
H S
transport/binding proteins and
metabolism of nucleotides and
#15
topA
spoIIE
accD
(ylbN)
(ylbM)
ypjD
ywnA
ysiA
-181 : -170
-72 : -61
-192 : -172
-59 : -52
-151 : -158
-50 : -58
-52 : -40
-86 : -70
______GTTTGACAAACG
______TTTTGACAAAAT
GACAGCGTTTGACAAAAAAAG
________TTGACAAA
________TTGACAAA
_______TTTGACAAA
________TTGACAAACGAAT
_AATAAACTTGACAAACC

Spo0A,SigA






H S
H S
S
H S
H S
H S
H
S
DNA packaging and segregation,
sporulation, [ functionally related to topA]
metabolism of lipids
none
none
none
none
regulation
#16
yqeG
dnaA
yvyD
spo0A
(yqgX)
(yqgW)
-96 : -80
-144 : -129
-95 : -110
-183 : -191
-89 : -82
-69 : -76
_____TTTGTCGAAATTTTTTT
___AATTTGTCGAAAAGCT
TGAACTTTGTCGAATT
_____TTTGTCGAA
_____TTTGTCGA
_____TTTGTCGA



Spo0A


H S
S
H
H S
H S
H S
none, [ clustered together with dnaA in #24 ]
DNA replication, [ clustered together with yqeG in #24 ]
initiation
regulation
none
none
#17
treP
treP
-43 : -20
-60 : -81
AGTTGTATATACAAGTTATAAAAA
TCCTGTATATAC-AGGTAGTCAA
TreR
TreR
H
H
transport/binding proteins and lipoproteins
transport/binding proteins and lipoproteins
#18
ypjA
ypjA
ytcG
-89 : -78
-95 : -104
-182 : -171
_GTCAGCTTTTTT
_GTCAGCTTTT
TGTCAGCTTTTT



H S
H S
H
none
none
none
#19
trpS
spoIID
pbuG
pyrG
-40 : -28
-159 : -148
-62 : -51
-118 : -102
____CCTTTTTTATTAT
____GGTTTTTTATTT
____CGTTTTTTATTT
GGAGC-TTTCTTATTTTC




H S
H
S
S
aminoacyl-tRNA synthetases
sporulation
transport/binding proteins and lipoproteins
metabolism of nucleotides and nucleic acids
#20
purE
xpt
-226 : -184
-172 : -158
ACCTCATATAATCTTGGGAATA..
CACTCATATAATCGC


H
H S
metabolism of nucleotides and nucleic acids
metabolism of nucleotides and nucleic acids
#21
pnpA
pnpA
asnS
-157 : -167
-154 : -142
-122 : -108
___CTCCCGCTTTT
___TTCCCGCTTTTTT
GAAAAGCCGCTTTTT



H S
H S
S
metabolism of nucleotides and nucleic acids
metabolism of nucleotides and nucleic acids
aminoacyl-tRNA synthetases
#22
ykvJ
nadB
yqxD
-153 : -134
-80 : -65
-80 : -64
_CCCTCTATAAAAAACTAAGG
_____CCATAAAAAACTCTTG
TATTATAATAAAAAATT


SigA
H S
H
H
none
metabolism of coenzymes and prosthetic groups
none
#23
sigG
lonB
-50 : -38
-62 : -53
CCAAGGAGATACT
____GGAGATACTA
SigG

H S
H S
initiation
adaptation to atypical conditions
#24
dnaN
yqeG
yqeG
dnaN
dnaA
yqeG
ywlC
-87 : -77
-125 : -117
-231 : -208
-115 : -130
-216 : -209
-187 : -200
-143 : -130
_________TTATCCACAAA
_________TTATCCACA
..CGTTCTGTTATCCACA
__________TATCCACATGTGGACA
__________TATCCACA
___CACAAGTTATCCAC
___ACATACTTATCCAC







H S
H S
S
H S
H S
H S
H
DNA replication
none
none
DNA replication
DNA replication, [ clustered together with yqeG in #16 ]
none, [ clustered together with dnaA in #16 ]
none
#25
(ylbN)
(ylbM)
rpoB
accD
phoP
-62 : -74
-148 : -136
-95 : -79
-53 : -61
-181 : -169
______TTTTTTCTTTACA
______TTTTTTCTTTACA
AAACCCTTTTTTCTTTT
_______TTTTTCTTT
_____CCTTTCTCTTTTT





H S
H S
H S
H S
S
none
none
elongation
metabolism of lipids
regulation
#26
trmU
dapF
sspD
-95 : -32
-82 : -63
-9 : -2
..CTTTATGAAAAACTGGGATGA..
_____TATGAAAAACGGGGGATAAT
______ATGAAAAA



S
S
H S
RNA modification
metabolism of amino acids and related molecules
sporulation
#27
qoxA
fruR
abrB
-153 : -129
-174 : -160
-60 : -52
AATTTTTGTCGATTTTATGACATTT
_ATTTTTGTCGAATTT
_____TTGTCGAAT


Spo0A
H
H
H S
membrane bioenergetics
regulation
regulation
#28
glpD
csgA
-50 : -30
-87 : -75
GCTGTTGTGGTCTCTTTTTCT
________TGTCTCTTTTTTT


H
S
specific pathways
sporulation
#29
aroF
aroA
-41 : -21
-138 : -125
TCTTACTTAAAAGCGTTAATG
____ACTTAAAAGCGTTT


S
H
metabolism of amino acids and related molecules
metabolism of amino acids and related molecules
#30
yclN
yfhC
-98 : -79
-41 : -26
AATGATAATGATAATCAATT
_____AAATGATAATCATTTT


H
H
transport/binding proteins and lipoproteins
none
#31
rplM
ydhG
ydhG
-18 : -7
-17 : -6
-215 : -197
___TTTAGGAGGGGA
__TTTTAGGAGGGA
AGTTTTAGAAGGAAAGAGC



H S
H
H
ribosomal proteins
none
none
#32
ydeT
ydeT
ylpC
yvgX
-164 : -180
-31 : -20
-52 : -23
-37 : -27
CGTCATTATATAAACTT
_____TTATATATTGAT
____ATTATATACTACTATTAGT..
___TTTTATATACC




H
H S
H S
H
regulation
regulation
none
transport/binding proteins and lipoproteins
#33
spoIIGA
spoIIGA
-126 : -109
-85 : -70
___AGCAGA-TTTCCCTGAAAA
ATTGACAGACTTTCCC
Spo0A
Spo0A
S
H S
sporulation
sporulation
#34
pyrR
pyrP
-129 : -107
-153 : -139
AGTCCAGAGAGGCTGAGAAGGA-T
AATCCAGAGAGGTTG
PyrR
PyrR
H
H S
regulation
transport/binding proteins and lipoproteins
#35
yqiC
mrpF
-65 : -40
-34 : -19
ACATGACATTTGAAGAAGCGATGAAA
______CATTTGAAAAAGCCAT


S
H
metabolism of nucleotides and nucleic acids
detoxification
#36
thiC
ylmB
-180 : -147
-136 : -123
_GGACCTGATCTGGTTCGTACCA..
TTGACCTGATCTGG


H
H
metabolism of coenzymes and prosthetic groups
metabolism of amino acids and related molecules
#37
xpt
ilvB
ripX
bglP
ileS
-35 : -22
-81 : -71
-33 : -22
-114 : -98
-41 : -33
___ATGCTTTTTTTATT
_____GCTTTTTTTAT
_____TCTTTTTTTACC
ATTTAGGTTTTTTTATT
_____GCTTTTTTT





S
H S
H S
H
H S
metabolism of nucleotides and nucleic acids
metabolism of amino acids and related molecules
phage-related functions
transport/binding proteins and lipoproteins
aminoacyl-tRNA synthetases
#38
hit
(hit)
(ecsA)
ecsA
-148 : -163
-202 : -218
-173 : -152
-283 : -270
__________AGCACCTCATTTGTCA
______GATAAACACCTCATTTG
GTCTTTGACAAACACCTCATTT
__________AACACCTCATTT




S
S
S
S
adaptation to atypical conditions
adaptation to atypical conditions
transport/binding proteins and lipoproteins
transport/binding proteins and lipoproteins
#39
proB
valS
-64 : -54
-71 : -62
TTCGTCCTTAT
TTCGTCCTTT


H S
H S
metabolism of amino acids and related molecules
aminoacyl-tRNA synthetases
#40
yrvE
yneE
yjbD
rpsJ
-33 : -20
-54 : -36
-91 : -84
-207 : -188
___TCTAGTATAATAGG
TTCTTTTGTATAATAGAGA
_______GTATAATA
______TGTATAATAAAAAAAGTGTG




H S
S
H S
H
DNA recombination
none
none
ribosomal proteins
#41
ylqF
dnaB
-111 : -97
-95 : -83
AACAAGCTCTTTTTT
__CTAGCTCTTTTCT


H
H S
none
DNA replication
#42
(nadB)
(nifS)
yrvO
-50 : -26
-54 : -77
-20 : -36
TTGTGTAAATATAGGTGTCAAGACA
_TGTGTAAATATAGGTGTCAAGACA
_____TAAATATAGAACATATA
SigA
SigA

H
H S
H S
metabolism of coenzymes and prosthetic groups
metabolism of coenzymes and prosthetic groups
miscellaneous
#43
ytfP
ytmQ
argC
carA
-117 : -83
-155 : -132
-67 : -40
-39 : -54
..CGGGCGTTTTTTATACAGCGC
_______CGTTTTTATACAT-GG..
TTGAATTAATTTTTATTCA-TGT..
____ATGAATTTTTATGCCT


AhrC

S
H
H S
H S
none
none
metabolism of amino acids and
metabolism of amino acids and
#44
tsf
tsf
-74 : -56
-83 : -93
G-CCTTTTATCACCTTTTTT
______TTATCACCTTT


H S
H S
elongation
elongation
#45
cysE
cysE
-57 : -43
-70 : -82
_CAGAGACGCTTTTTT
ACAGAGACGCTTT


H S
H S
metabolism of amino acids and related molecules
metabolism of amino acids and related molecules
#46
(ywjE)
(ywjF)
ykuF
ysiA
ysiA
-58 : -78
-97 : -77
-38 : -15
-44 : -37
-32 : -24
___TGACTGAACACTCATTCATTA
___TGACTGAACACTCATTCATTA
TATTGAATGAATAATCATTCACAA
__ATGAATGA
______________TCATTCATT





H
H
H
H S
H S
metabolism of lipids
membrane bioenergetics
specific pathways
regulation
regulation
#47
yvfK
bglS
msmX
mfd
-51 : -24
-34 : -19
-22 : -35
-48 : -34
..T-TAAAGCGCTTTCAT
__TAGAAAACGCTTTCAA
____GTAAACGCTTTCTT
_GACCAAAGCGTTTTT

CcpA
CcpA

H
H
H S
H S
transport/binding proteins and
specific pathways
transport/binding proteins and lipoproteins
elongation
#48
mntA
yqgU
rnmV
-119 : -104
-61 : -50
-40 : -52
GGGAAACTTTTTGTCC
CTGAAACTTTTT
_TGAAACTTTTTCT
MntR


H
H
S
transport/binding proteins and lipoproteins
none
RNA modification
#49
ydfM
yeaB
-129 : -102
-73 : -58
..CAACGTTGCTATAGACCCACTC..
_____TGTTTCTGTAGACCCA


H
S
transport/binding proteins and lipoproteins
transport/binding proteins and lipoproteins
#50
ybxA
gcvT
ykvJ
hutH
-75 : -64
-55 : -42
-115 : -101
-51 : -39
_ATGCCCTTTTTT
TCTGTCCTTTTTTG
TACGGCCTTTTTTAT
___CTCCTTTTTGTAT




H S
H S
S
H S
transport/binding proteins and lipoproteins
metabolism of amino acids and related molecules
detoxification
metabolism of amino acids and related molecules
#51
rplK
rplA
-54 : -43
-44 : -35
TGAGTGGGAGGG
___GTGGGAGGT-T


H S
H S
ribosomal proteins
ribosomal proteins
#52
kduI
araA
odhA
-72 : -52
-39 : -28
-101 : -88
ATTTTCTTTGAAACCGTTACC
______TTTGAAAGCGTT
______GTTGGAAGCGTTTT



H
H
H
specific pathways, [ close to araA on metabolic pathway ]
specific pathways, [ under glu
TCA cycle, [ likely to be unde
#53
prfA
acsA
-47 : -25
-47 : -34
TATACTATAATGAGAATGTTACG
TATACTATAATAAT

SigA
H
H
termination
specific pathways
#54
rpsD
rpsP
-186 : -173
-31 : -22
CTTTGTGTGAAATA
__TTGT-TGAAAT


H
H S
ribosomal proteins
ribosomal proteins
#55
yciA
yciC
-46 : -30
-36 : -23
A-ATAAATAGTAATTATT
____AAATCGTAATCATT

Zur
H
H
none
transport/binding proteins and lipoproteins
#56
yabM
yuiD
ybbP
-82 : -69
-116 : -105
-91 : -80
_TGTGGTATAATAAC
__ATGGTATAATAG
ATGTGGTATAAT



H
H
H S
transport/binding proteins and lipoproteins
none
none
#57
ysdB
pgi
parE
-74 : -60
-45 : -32
-131 : -117
_AGAAAAAGTGAAACC
____TAAAGTGAAAGATG
ACTGAAAAGAGAAAG
SigW


H
H S
H
none
main glycolytic pathways
DNA packaging and segregation
#58
pdhA
metK
yusC
-139 : -128
-133 : -122
-70 : -55
_ATAAAAGGTTTT
__GAAAAGGTTTTT
GCAGAAAGGCTTTTCT



H
H S
H
main glycolytic pathways
metabolism of amino acids and related molecules
transport/binding proteins and lipoproteins
#59
bglP
sucC
-255 : -239
-57 : -42
____AAATGAAAGCGTTGACA
TATAGAATGAAAGCGC
CcpA

H
S
transport/binding proteins and lipoproteins
TCA cycle, [ under glucose rep
#60
rocF
pcrB
ydbS
-54 : -42
-48 : -37
-121 : -109
_TCTTTGTTATAAC
___TTTGTTATAATG
TGATTTGTTATTC



S
H S
S
metabolism of amino acids and related molecules
miscellaneous
none
#61
yckC
ptsG
-118 : -105
-114 : -125
GTCAAGAGGCATGA
__AAAAAGGCATGA


H
H S
none
transport/binding proteins and lipoproteins
#62
yvcI
(nudF)
(yqkF)
-229 : -211
-68 : -57
-192 : -203
AAGTAATTGACCCCCTTTT
_________GCCCCCTTTTGC
_________GCCCCCTTTTGC



H S
S
S
DNA restriction/modification and repair
specific pathways
specific pathways
#63
rpsD
yloI
-49 : -29
-54 : -37
AGACGGTTTTTATTTTCCA-CA
__TAGGTTGTTATTTTTTTC


H
H S
ribosomal proteins
metabolism of coenzymes and prosthetic groups
#64
ilvB
leuS
-280 : -262
-240 : -228
_AACTCGCCTCAGAGTGCCA
GAACTCACCTCAG


H S
S
metabolism of amino acids and related molecules
aminoacyl-tRNA synthetases
#65
bkdAA
yvgZ
ywrD
-45 : -23
-85 : -71
-149 : -133
GATGGCAAAGCCATTCATTTTTA
____________ATTCATTTTTTG..
______ATAATTTTTCATTTGTT



H S
H
H S
metabolism of lipids
none
metabolism of amino acids and related molecules
#66
(ezrA)
(hisJ)
ydcD
-116 : -89
-81 : -108
-68 : -55
TTACATGGTATCATAATAACAATG..
TTACATGGTATCATAATAACAATG..
__TAATGGTATCATTA



S
S
S
cell division
metabolism of amino acids and related molecules
none
#67
(ydeD)
(ydeC)
tig
mutS
yloC
-26 : -43
-87 : -70
-196 : -174
-55 : -47
-78 : -67
ATAATAGTGTTATAATAA
ATAATAGTGTTATAATAA
_____TATGTTATAATATAGTGGT..
_______TGTTATAAT
____ATATGATATAAT





H
H
H
H S
S
none
regulation
protein folding
DNA restriction/modification and repair
none
#68
yunB
yqfZ
-39 : -25
-47 : -33
CTTACAAGCATACAT
_GGACAAGCATACTAT


S
S
none
none
#69
uppS
yneP
yuxL
-80 : -66
-120 : -109
-73 : -60
AGGGGGTTTTTTTGT
___TGGTTTTTTTCT
__CGCTTTTTTTTGCT



H
S
S
metabolism of lipids
none
metabolism of amino acids and related molecules
#70
gmk
gmk
-79 : -48
-153 : -139
TCTGCGCCAATCAAACGGATGATT..
_______CGATTAAACTGATTA


H
H
metabolism of nucleotides and nucleic acids
metabolism of nucleotides and nucleic acids
#71
ytsP
yhcQ
-275 : -246
-22 : -7
_TAGAAAAAGTGAGGGTT-TTCCA..
GAAAAAAAAG-GAGGAA


S
H
none
none
#72
yusC
yeaB
-122 : -99
-124 : -111
GCTTTGAAAGATGAGAGAAAGGCA
__________ATGAGAGAAAAAGT


H
S
transport/binding proteins and lipoproteins
transport/binding proteins and lipoproteins
#73
ykuL
purE
dacB
-102 : -91
-47 : -34
-94 : -81
TCTTTTTTATTG
TATTTTTTATTTTC
__TTTTTTATGTTTGC



S
H
H
none
metabolism of nucleotides and nucleic acids
cell wall
#74
yosT
kduI
-43 : -29
-134 : -120
_ATTTTTAATCATATT
TTTTTTTAATAATAT


H
H
none
specific pathways
#75
glcR
yvgL
-45 : -28
-39 : -22
ACTTATAATTACTTATAA
AGTTATAATTAGTTATAT


H
H
regulation
transport/binding proteins and lipoproteins
#76
dnaJ
vpr
-105 : -82
-38 : -19
CTTGGCTTTGACTTTTTTTCTTGC
____TCTTTCACATTTTTTCTAAA


S
H
adaptation to atypical conditions
metabolism of amino acids and related molecules
#77
clpX
smpB
-97 : -84
-64 : -53
TATGGTAAAAT-GC-A
TTTGGTAAAATA


S
S
adaptation to atypical conditions
protein modification
#78
argC
yraN
ydeC
-86 : -70
-78 : -63
-37 : -24
____AAAAATAT-TAAATATAC
__AATAAAATATAAGTTT
ATGAAAAAATATAA
AhrC


H S
H
H
metabolism of amino acids and related molecules
regulation
regulation
#79
ydhM
(ywhE)
(speE)
-75 : -36
-110 : -102
-92 : -100
ATAAAAGTATAGACATTTAAAATT..
____AAGTATAGA
____AAGTATAGA



H
H S
H S
transport/binding proteins and lipoproteins
cell wall
metabolism of amino acids and related molecules
#80
cysH
mtrA
-297 : -282
-48 : -38
AATTGTGCTAAAATTT
___TGTGCTAGAAT


S
H S
metabolism of amino acids and related molecules
metabolism of coenzymes and prosthetic groups
#81
ytoI
comGA
-43 : -31
-154 : -144
CCTTATAATAAAA
__TTATAATGACA


S
H S
none
transformation/competence
#82
yitJ
yjcI
-76 : -53
-58 : -43
TGACAAAGTCTTCTTCTTA-AGAGG
____AACCCCTTCTTCTTAT


S
H
none
metabolism of amino acids and related molecules
#83
pta
yrhP
-235 : -218
-41 : -30
T-TCACTATACCATAGTTT
__TCACTATATGAT


S
S
specific pathways
transport/binding proteins and lipoproteins
#84
hisZ
yuiF
-64 : -43
-30 : -15
ATATTAGCGAACTAAAGGATTC
________AAACTAAAGGATTTTT


H
H
aminoacyl-tRNA synthetases
none
#85
lexA
ytsC
-139 : -124
-78 : -70
AGGAATGTTTGTTCGC
_____T-TTTGTTCG
LexA

H
H S
regulation
transport/binding proteins and lipoproteins
#86
ylxM
iolD
-38 : -11
-159 : -137
..GGGATTTGACTTAACAAAGGG
______ATTCGCTTAACAACTGCG..


H S
S
none
specific pathways
#87
sigG
sdhC
-67 : -53
-180 : -171
GTGCATATTTTTCCC
____AAATTTTTCA
SigG

H S
H S
initiation
TAC cycle
#88
serS
leuS
-56 : -38
-110 : -99
TGGGGATGAGGGCTCTTTT
TTGGGATGAGGG


H S
H S
aminoacyl-tRNA synthetases
aminoacyl-tRNA synthetases
#89
(gcvT)
(yqhH)
rpsF
-231 : -213
-211 : -229
-38 : -50
AGGCGCCGAAGGAGCAAAC
AGGCGCCGAAGGAGCAAAC
____GGGCAAGGAGCAA



S
H S
H
metabolism of amino acids and related molecules
DNA recombination
ribosomal proteins
#90
(ypbB)
(fer)
polA
-60 : -47
-206 : -219
-73 : -61
TCTGTTAAAATAAA
TCTGTTAAAATAAA
T-TGTTAAAATAAG



H
H
H
none
membrane bioenergetics
DNA replication
#91
(sppA)
(ytdI)
yclA
-54 : -41
-132 : -145
-54 : -65
_ATTTTTCATATTGA
_ATTTTTCATATTGA
TATTTTTCATAT



H
H
S
protein modification
none
regulation
#92
(yrrT)
(yrzA)
yrzA
-17 : -33
-174 : -160
-48 : -28
_____ATTTAATAATTCCTATA
_______TTAATAATTCCTATA
AAAAAAGCTTATACTTCATAT



S
S
S
none
none
none
#93
ylbH
ylxS
-256 : -197
-154 : -124
..AACTTATGGGGAAACGTAAGTC..
__AAAGAGTGGGGAAACCCGCTCT..


H
H
none
none
#94
yjcH
yitJ
-198 : -183
-176 : -189
_GGGCCAGT-CCCTCCAC
CGGGCCAGTCCCTC


S
S
none
none
#95
yhdE
ypfA
deoD
-68 : -57
-70 : -55
-114 : -97
____TTCCTTTTTTTT
GTCTTTTCCTTTTTTT
__CATTTCTTTTTTCGATAT



H S
S
S
none
none
metabolism of nucleotides and nucleic acids
#96
yeaD
yuxG
nusB
-300 : -262
-74 : -95
-237 : -218
..CTGGTTTTTGTTTTAC
______TTTTTGTTTATTTTTGCT..
CTTTGGTTTTTTT



S
H
S
none
specific pathways
termination
#97
yqgN
ydeM
-109 : -80
-42 : -24
..ACACCGTGAAACAAAATAA-CA..
_____AAAATAAACAAAATAGACA


H
S
metabolism of coenzymes and prosthetic groups
none
#98
mrpA
veg
-173 : -157
-74 : -60
AAAGTGCGATATAATTT
__ACGTTGATATAATTT


H
H
transport/binding proteins and lipoproteins
miscellaneous
#99
yugT
tdk
-108 : -93
-56 : -45
CAAACGGCTGTTTTTT
____TGCCTGTTTTTT


S
H S
specific pathways
metabolism of nucleotides and nucleic acids
#100
fabHB
spoIIP
-106 : -93
-42 : -30
_TTTTCATAGATTCC
TTGTTCATAGAGT

sigE
H
H
metabolism of lipids
sporulation
#101
sapB
ytsA
-63 : -52
-45 : -35
TTTTGCTATAAA
TTTTGCTATAC


H
H S
miscellaneous
regulation
#102
ruvA
yjcH
-39 : -23
-57 : -46
TTATGGTACAATGAAGA
__ATGGTACAATAA


H
H S
DNA recombination
none
#103
ywkC
rpoB
-94 : -77
-62 : -47
CCACTTTCTTTGCCGAAT
_TTCTTTCTTTGGAAGA


H S
H
none
elongation
#104
rnpA
yphA
-116 : -103
-78 : -88
ATGGGAAAAGATAG
ATGGGAAAAGA


H
S
RNA modification
none
#105
rnpA
ywaC
-140 : -124
-117 : -106
ATGTCAGTGGTCTTTTT
________GGTCTTTTTTTG


H
H
RNA modification
metabolism of nucleotides and nucleic acids
#106
spoIIIE
lepA
-102 : -91
-53 : -44
TATGCTATAATA
_TTGATATAAT


H
H S
sporulation
elongation
#107
mta
lcfA
hepS
arfM
-109 : -98
-76 : -62
-104 : -94
-139 : -123
__________TTTCTTTTATAC
__CCTTTCTTTTTCTTT
____TTCTTTTTTTT
ATCCTCCTTTTTTCTTT




H S
S
H
S
regulation
metabolism of lipids
metabolism of coenzymes and prosthetic groups
regulation
#108
gatB
sspO
-134 : -106
-174 : -157
..CAAAAATTTTCTCAAGC
__TCACAATTTTCTCACAAT


S
H
aminoacyl-tRNA synthetases
sporulation
#109
clpP
polA
-225 : -209
-93 : -80
TAATTCCTTTCAAATAA
_TTTTCCTTTCAAAT


H
H
adaptation to atypical conditions
DNA replication
#110
alaS
metS
-62 : -47
-36 : -27
AGGGGGAGGGCTTTTT
_____GGGAGCTTTT


H
H S
aminoacyl-tRNA synthetases
aminoacyl-tRNA synthetases
#111
(yjbL)
(yjbK)
yukF
-45 : -30
-80 : -94
-24 : -10
ATATGATAAAATGAAT
ATATGATAAAATGAA
TCATAATAAAAGGAA



H
H S
S
none
none
none
#112
valS
proB
tyrS
serS
-244 : -232
-223 : -215
-248 : -237
-229 : -221
TGCAGAGAGAG-AA
GACAGAGAG
TCCAGAGAGCTG
_TAAGAGAGC




H S
H S
S
H S
aminoacyl-tRNA synthetases
metabolism of amino acids and related molecules
aminoacyl-tRNA synthetases
aminoacyl-tRNA synthetases
#113
yqeC
lcfA
-119 : -105
-92 : -83
TGAAAAATAAAATTT
_GAAAAAGAAA


H
H S
main glycolytic pathways
metabolism of lipids
#114
yurY
citS
-49 : -28
-61 : -45
AATGAGAATAAAATGAGAATAA
________AAAAATGAGAAAATTCC


H S
H
transport/binding proteins and lipoproteins
sensors (signal transduction)
#115
spoIIQ
yshC
-73 : -60
-55 : -43
TAAAAAAGTTTTTT
__GAGAAGTTTTTTT


H S
H
sporulation
DNA restriction/modification and repair
#116
yuxN
ywhE
-265 : -245
-45 : -32
CATTTTTTCTC-TGACAAGGTC
__TTTTTTCTCATAAT


S
S
none
cell wall
#117
ydeT
ydeT
-46 : -40
-191 : -185
TATATAA
TATATAA


H S
H S
regulation
regulation
#118
ydeB
yqzD
-43 : -4
-36 : -20
..TAAGAAGGATACCATATATGGA..
__AAAGAAGGATACAAAAA


H
H
regulation
none
#119
pbuG
xpt
-203 : -194
-155 : -147
GGAATATGGC
_GGATATGGC


H S
H S
transport/binding proteins and lipoproteins
metabolism of nucleotides and nucleic acids
#120
rpsD
spoVAA
-78 : -60
-58 : -41
______AAAACAAAATGTGCATGGT
GAATGAG-AACAAAATCGA


H
S
ribosomal proteins
sporulation
#121
purR
yprA
-26 : -15
-39 : -33
AATATTCGGATT
AATATTC


H S
H S
regulation
DNA restriction/modification and repair
#122
ackA
gcaD
-128 : -122
-65 : -59
CTTGAAA
CTTGAAA

SigA
H S
H S
specific pathways
cell wall
#123
(yqhR)
(yqhQ)
ykvJ
-147 : -155
-80 : -72
-172 : -162
__TAGAGGTTT
__TAGAGGTTT
GGGAGAGGTT-C



H S
H S
H S
none
none
detoxification
#124
ydcK
yrrK
-191 : -162
-258 : -240
..TTCAGCAGTTTAATTT
AACGATGAAATTTAATTT


H S
H S
none
none
#125
(yjbE)
(mecA)
rapG
-128 : -145
-147 : -132
-83 : -66
__GTTTTATCATAAAATAGA
___TTT-ATCATAAAATAGA
AGGATTTTACATAAAATA

DegU

H
H S
H
none
transformation/competence
sporulation
#126
nusB
yshA
-65 : -50
-46 : -35
AAATATGTTATGATCT
___CGTGTTATGATA


H S
H
termination
none
#127
yhbH
safA
cotE
-107 : -91
-19 : -9
-40 : -32
TATGTGCATATGATGAA
____TGCATAGGAGG
_____GCATAAGAT


SigK
H S
H
H S
none
sporulation
sporulation
#128
ytkK
pbuG
-108 : -96
-278 : -269
TTTTTTTGTATGC
___TTTTGTATTG


S
H S
metabolism of lipids
transport/binding proteins and lipoproteins
#129
ywfK
sdhC
-64 : -47
-106 : -95
ATATGAGTACAATAAAGA
___GGAGTAAAATGA

SigA
S
H S
regulation
TAC cycle
#130
ytkK
ctsR
-66 : -48
-52 : -40
TTTATAGTAAAGTAGAAGA
__TATAGTAAGATTA


S
H S
metabolism of lipids
regulation
#131
yjbD
acuA
-67 : -48
-102 : -93
TTTTAGAGTAATTTCAATTT
__________TTCTCAATTT


S
H S
none
specific pathways
#132
rplJ
yqhH
-164 : -145
-104 : -95
CTTAATTATCCTACCGAGGT
______TATCCTACCA


H S
H S
ribosomal proteins
DNA recombination
#133
maf
ecsA
-59 : -48
-39 : -28
ATTTGGTAGGAT
_TTTGGTACTATG


H S
H S
cell division
transport/binding proteins and lipoproteins
#134
ykvJ
sdhC
-251 : -231
-119 : -131
ACTTTTTTATTGTCAAGAAAA
_________GCGTCAAGAAAAC

SigA
H
H S
none
TAC cycle
#135
divIB
divIB
-88 : -71
-54 : -65
AAACGAACAAACGGCATC
_____AACAAACGGCAT


S
H S
cell division
cell division
#136
(yloB)
(yloA)
yllA
-85 : -69
-31 : -47
-44 : -59
___ATTATAGCATGAAATGG
___ATTATAGCATGAAATGG
ATGAGTATAGCATGTT



H
H
S
transport/binding proteins and lipoproteins
adaptation to atypical conditions
none
#137
ykrT
ykrT
-56 : -36
-59 : -71
TCTGAGAAGGAGGCTTTTTTA
_____GAAGGAGGCTTAA


S
S
none
none
#138
yjdA
yheC
-116 : -100
-136 : -148
__AAGCTGATTTTAAAATG
ACAAGCTGATTTT


H
S
metabolism of lipids
none
#139
(ypjD)
(ypjC)
ydfS
-267 : -210
-95 : -144
-19 : -30
..TCAGCCAGATTGTTCTGCATAT..
..TCAGCCAGATTGTTCTGCATATT
____TCCCAGATTGTT



H S
S
H
none
none
none
#140
(ezrA)
(hisJ)
hemE
-138 : -120
-59 : -77
-101 : -113
ATTTCTGGTCAAAAAATGT
ATTTCTGGTCAAAAAATGT
________TCAAAAAATCGCC



S
S
H S
cell division
metabolism of amino acids and related molecules
metabolism of coenzymes and prosthetic groups
#141
(yqeW)
(rpsU)
rpsF
-94 : -82
-70 : -82
-85 : -69
___ATTATAATATAAG
___ATTATAATATAAG
TTTGGTATAATATAAAA



H
H
H
transport/binding proteins and lipoproteins
ribosomal proteins
ribosomal proteins
#142
(rpsT)
(gpr)
soj
-86 : -73
-118 : -131
-54 : -35
_TTTGATAGAATACA
_TTTGATAGAATACA
TTTTGATAGAATAGA-AGCAA



H
H
H
ribosomal proteins
germination
sporulation
#143
perR
yesO
-58 : -21
-85 : -63
..AAACATTACAATGTAAGAATTT..
___AAAATAA-AATGTAAGCACTT..


H
H
regulation
transport/binding proteins and lipoproteins
#144
xpt
rsbR
-85 : -67
-84 : -72
GTACGGTTTTTTGTGATAT
____CTTTTTTTGTTTT

SigA
H
H
metabolism of nucleotides and nucleic acids
adaptation to atypical conditions
#145
sspF
metE
-145 : -129
-205 : -195
TTTGTTTACTGCTTTTT
_____GCACTGCTTTT


S
H
sporulation
metabolism of amino acids and related molecules
#146
yqxK
glyA
-269 : -236
-82 : -66
..ACATTCATATCGGCCGGACC
___CTTTTACATCGGCCTTA


S
S
none
metabolism of amino acids and related molecules
#147
ygaH
ytsC
-175 : -154
-54 : -65
TCATCAAATTCTTTTCCTTCTA
___________TTTTCCTTCGAT


S
H S
none
transport/binding proteins and lipoproteins
#148
serS
yfkD
-185 : -171
-51 : -63
GAATCCATCCTTGAG
TTATCCATCATTT


H S
H
aminoacyl-tRNA synthetases
none
#149
yhzC
proB
-170 : -157
-247 : -236
AAATGACTAGTAAT
___GGATTAGTAAGC


H
H S
none
metabolism of amino acids and related molecules
#150
msmR
yuiA
-90 : -73
-98 : -89
ATTATTGTAACCGCTTAC
_________TCCGCTTACA


H
H S
regulation
none
#151
comGA
ldh
-86 : -71
-50 : -43
ATAACATCTCACAAAA
_______TTCACAAA


S
H S
transformation/competence
membrane bioenergetics
#152
yvcI
ywlE
-161 : -154
-43 : -36
TTTTTTGT
TTTTTTCT


H S
H S
DNA restriction/modification and repair
protein modification
#153
gcaD
yvsG
-30 : -19
-20 : -13
ATGGATAAAAGG
___GATAAAAG


H S
H S
cell wall
none
#154
leuS
alaS
-195 : -187
-159 : -152
CTGCGTTAA
CTGCGTTA


H S
H S
aminoacyl-tRNA synthetases
aminoacyl-tRNA synthetases
Known or suggested co-regulated genes are shown in green while plausible co-regulated genes predicted in this study are shown in red.
a Rank of clusters: clusters are ranked by the highest pairwise score within each.
b Pair of gene names are shown in parentheses when PCE exists on both of their upstream regions.
c Position of PCE from the translation start site.
d Sequence of PCE in B. subtilis. Only similar region is shown when too long.
e Transcription factors and sigma factors that bind to the PCE.
f Species having the PCE; H: B. halodurnas, S: B. stearothermophilus
g Basically taken from the SubtiList web site. Our own comments are added when appropriate.