Transcription factor: PyrR

Factor type ND
SWISS-PROT ND
SubtiList ND
Consensus seq. ARUCCNGNGAGGYU
Comment Involved in repression of the pyr operon by transcriptional attenuation in the presence of excess UTP. Tight binding to the pyr mRNA requires the (C)NGNGA sequence.
Link to Phylogenetic profile

Operon Regulated Gene Sigma Regulation Absolute position Location Binding seq.(cis-element) Experimental evidence
pyrRPBCAAABKDFE pyrR SigA Negative 1618156..1618215 None TGAATAGATTCTTTAAAACAGTCCAGAGAGGCTGAGAAGGATAACGGATAGACGGGATGC Lu Y, et al. (1995): DB RG
Turner RJ, et al. (1994): NB RG DP OV
Ghim S-Y & Switzer RL (1996): Classical genetics, RG
Lu Y & Switzer RL (1996): Titration
Lu Y & Switzer RL (1996): RO NB, in-vitro transcription
Lu Y, et al. (1996): In-vitro transcription
Bonner ER, et al. (2001): GS FT
Zhang H & Switzer RL (2003): RO
pyrRPBCAAABKDFE pyrP SigA Negative 1618850..1618910 None TAGATCACCTTTTTAAGGGCAATCCAGAGAGGTTGCAAAGAGGTGCACAACAAAGGCCCAA Turner RJ, et al. (1994): NB RG DP OV
Lu Y, et al. (1996): DB RG
Ghim S-Y & Switzer RL (1996): Classical genetics, RG
Lu Y & Switzer RL (1996): Titration
Lu Y & Switzer RL (1996): RO NB, in-vitro transcription
Turner RJ, et al. (1998): GS DP
Bonner ER, et al. (2001): GS FT SDM
Zhang H & Switzer RL (2003): RO
Zhang H, et al. (2005): SDM RG
pyrRPBCAAABKDFE pyrB SigA Negative 1620326..1620385 None TTTAAAACCTTTTAATGAAAGTCCAGAGAGGCTTGGAAGGGTTATGAAGAGAAGGAAGCT Lu Y, et al. (1996): DB RG
Quinn CL, et al. (1991): S1
Turner RJ, et al. (1994): NB RG DP OV
Ghim S-Y & Switzer RL (1996): Classical genetics, RG
Lu Y & Switzer RL (1996): Titration
Lu Y & Switzer RL (1996): RO NB, in-vitro transcription
Bonner ER, et al. (2001): GS FT
Zhang H & Switzer RL (2003): RO




Copyright: Human Genome Center, Inst. Med. Sci., Univ. Tokyo; 1999-2008
Contact: Kenta Nakai