Transcription factor: PurR

Factor type	Purine biosynthesis
SWISS-PROT	ND
SubtiList	ND
Consensus seq.	ANNNCGAA---22-23bp---ANNNTTCGNNNNT
Comment	a purine repressor which mediates adenine nucleotide-dependent regulation of pur operon. GAAC-N24-GTTC motif seems necessary for its binding but this motif was not required for its binding to purA
Link to	Phylogenetic profile, Weight matrix & Motif alignment

Operon	Regulated Gene	Sigma	Regulation	Absolute position	Location	Binding seq.(cis-element)	Experimental evidence
glyA	glyA	SigA	Negative	`3790541..3790600`	`-120:-61`	AATAAATTCCGAACTTTAAATTAAATTTAAGTTATTAATATTCGTTTTTACCAATAAAAA	Saxild HH, et al. (2001): HM DB RG DP SDM
guaC	guaC	None	Negative	`3302981..3303033`	None	TATATAAGGCGAACATTTCATATATTATACTTTTAAATATTCGTTTTTAGGAG	Saxild HH, et al. (2001): HM DB RG
nusB-folD	nusB	None	Negative	`2529763..2529815`	None	CGTGAAATCCGAATAATCATATTAAGGTGTGTGAAAATATTCGGTAATAGGGT	Saxild HH, et al. (2001): HM RG DB
pbuG	pbuG	None	Negative	`694338..694390`	None	TGTTTATTACGAACAAAATCCGATTTTGCGCGACTATTGTTCGCTTTTTGTAT	Saxild HH, et al. (2001): HM RG DB
purA	purA	SigA	Negative	`4156804..4156857`	`-88:-35`	GAATGGAAGCGAACGAATATAGATTTACAATAAATTAATGTTCGGATTTACAAT	Saxild HH & Nygaard P (1991): Enzyme activity measurement Weng M, et al. (1995): GS Shin BS, et al. (1997): GS FT Rappu P, et al. (1999): RG DP DB Saxild HH, et al. (2001): HM Rappu P, et al. (2005): RG SDM GS
purEKBCSQLFMNHD	purE	SigA	Negative	`698279..698342`	`-91:-28`	AATTGATCTAAAACACGAACATTAGTAGAATGAATTTTTGTATCGTTCGATAATATCGTTGACA	Ebbole DJ & Zalkin H (1987): S1 Ebbole DJ & Zalkin H (1989): RG Ebbole DJ & Zalkin H (1989): DP RG GS FT Saxild HH & Nygaard P (1991): Enzyme activity measurement Weng M, et al. (1995): GS FT DB DP RG Shin BS, et al. (1997): GS FT SDM Weng M & Zalkin H (2000): DB RG GS Saxild HH, et al. (2001): HM RG Bera AK, et al. (2003): GS DP, ultracentrifugation Xuan J, et al. (2005): GS SDM RG Qian J, et al. (2006): Classical genetics
purR-yabJ	purR	None	Negative	`54380..54432`	None	GATTAAATCCGTATGTTAAGTTATATTGATCTTAAAATATTCGGATTTTGGGG	Weng M, et al. (1995): GS RG DB Shin BS, et al. (1997): GS FT Saxild HH, et al. (2001): HM
pyrRPBCAAABKDFE	pyrR	SigA	Negative	`1618044..1618109`	`-110:-45`	GGAGAATATGTCGAATTTGAAGCGCCGCTTCCCGAGGATATGGCAGAATTAATCGAAAACCTCAGA	Shin BS, et al. (1997): GS FT
xpt-pbuX	xpt	SigA	Negative	`2320255..2320307`	`-97:-45`	CTTGAAATACGAATGATATCTAAAAAAACAAAATTAAAGTTCGGGAATTTTTA	Saxild HH, et al. (2001): HM RG DB
ytiP	ytiP	None	Negative	`3068849..3068902`	None	CAAATAAAACGAATAATATTAATGGTGTTTTGTTAAAACGTTCGTAATTGGAGG	Saxild HH, et al. (2001): HM DB RG