Transcription factor: HrcA

Factor type Unique(CIRCE)
SWISS-PROT P25499
SubtiList BG10662
Consensus seq. TTAGCACTC---------GAGTGCTAA
Comment the promoters of class I heat-inducible genes are sigA-dependent and have an inverted repeat, called the CIRCE (controlling IR of chaperone expression) element, which is highly conserved among eubacteria
heat-shock and general stress responses are reviewed in Hecker, M. et al., 1996
Link toPhylogenetic profile , Weight matrix & Motif alignment

Regulated
gene
Operon Sigma Regulation Absolute position Location Binding seq.(cis-element) Exp. Reference Year
groES groES-groEL SigA Negative 649388..649414 +5:+31 TTAGCACTCTTTAGTGCTGAGTGCTAA
HB GS Hecker M, et al. 1996
hrcA hrcA-grpE-dnaK-dnaJ (?) SigA Negative 2628875..2628901 +5:+31 TTAGCACTCGCTTATTGAGAGTGCTAA
SDM HB Zuber U, et al. 1994




Copyright: Human Genome Center, Inst. Med. Sci., Univ. Tokyo; 1999-2004
Contact: knakai@ims.u-tokyo.ac.jp