Transcription factor: SinR

Factor type Xre
SWISS-PROT P06533
SubtiList BG10754
Consensus seq.
Comment dual-function regulator which is essential for the late-growth processes of competence and motility and is also a repressor of others, e.g., sporulation and subtilisin synthesis
might be a leucine zipper protein
in aprE there are two binding sites and SinR binds more strongly to the distal site which contains two dyad symmetry sites
Link toPhylogenetic profile , Weight matrix & Motif alignment

Regulated
gene
Operon Sigma Regulation Absolute position Location Binding seq.(cis-element) Exp. Reference Year
aprE ND SigA Negative 1105150..1105195 -265:-220 ATTGTTCTCACGGAAGCACACGCAGGTCATTTGAACGAATTTTTTC
DP GS FT Gaur NK, et al. 1991
comK ND ND Positive ND ND ND
DB Hahn J, et al. 1994
rok ND ND Negative ND ND ND
gel shift Hoa, T. T., et al. 2002
spo0A ND SigH Negative 2518106..2518125 -23:-4 GTTTTGTCGAATGTAAACAT
DB GS FT Mandic Mulec I, et al. 1995
spoIIAA ND SigH Negative 2444244..2444263 -51:-32 GTTTTGTCACGGTGAAGGAA
DB GS FT Mandic Mulec I, et al. 1995
spoIIGA ND SigA Negative 1602944..1602958 -90:-76 AAATTAAGCAGATTT
GS FT Cervin MA et al. 1998
spoIIGA ND SigA Negative 1602962..1602977 -72:-57 TGAAAAATTGTATTTT
GS FT Cervin MA et al. 1998
spoIIGA ND SigA Negative 1602984..1602999 -50:-35 AACATTAATTGACAGA
GS FT Cervin MA et al. 1998




Copyright: Human Genome Center, Inst. Med. Sci., Univ. Tokyo; 1999-2004
Contact: knakai@ims.u-tokyo.ac.jp