Transcription factor: RocR

Factor type	NtrC/NifA
SWISS-PROT	P38022
SubtiList	BG10723
Consensus seq.	GCAAAATAATTTTGCA(T/C)T
Comment	NtrC/NifA transcriptional activator (cf. LevR). Sigma 54-dependent activators generally bind two inverted repeat sequences called UAS, which are located approx. 100bp upstream from the -12/-24 promoters. DNA bending is used for activation (AhrC may be involved). Inducible by ornithine or citrulline? At least upstream UAS1 is the target of RocR
Link to	Phylogenetic profile, Weight matrix, Motif alignment & Similar conserved hexameric motifs

Operon	Regulated Gene	Sigma	Regulation	Absolute position	Location	Binding seq.(cis-element)	Experimental evidence
rocABC	rocA	SigL	Positive	`3879729..3879752`	`-217:-194`	CCTCCGCAAAATAATTTTGCATTT	Ali NO, et al. (2003): FT DP Calogero S, et al. (1994): DB
rocABC	rocA	SigL	Positive	`3879680..3879708`	`-173:-145`	AAAACGCAAAATAAATTTGCGTTCAAGAT	Ali NO, et al. (2003): FT DP Calogero S, et al. (1994): DB
rocDEF	rocD	SigL	Positive	`4144687..4144707`	`-130:-110`	TATGCAAAAGAATTTTGCACT	Gardan R, et al. (1995): DP RG HM
rocDEF	rocD	SigL	Positive	`4144646..4144666`	`-89:-69`	ATATCAGAATGTTTTTGCACC	Gardan R, et al. (1995): DP HM
rocG	rocG	SigL	Positive	`3879729..3879752`	downstream of rocG	CCTCCGCAAAATAATTTTGCATTT	Belitsky BR & Sonenshein AL (1999): RG DP Ali NO, et al. (2003): FT DP
rocG	rocG	SigL	Positive	`3879680..3879708`	downstream of rocG	AAAACGCAAAATAAATTTGCGTTCAAGAT	Belitsky BR & Sonenshein AL (1999): RG DP Ali NO, et al. (2003): FT DP
rocR	rocR	SigA	Negative	`4144687..4144707`	`-50:-30`	AGTGCAAAATTCTTTTGCATA	Gardan R, et al. (1995): DB PE RG