| Factor type | LacI family |
|---|---|
| SWISS-PROT | P25144 |
| SubtiList | BG10376 |
| Consensus seq. | WTGNAANCGNWNNCW |
| Comment | also called AlsA common repressor in catabolite repression (CR) but may act as a positive regulator of genes involved in excretion of excess carbon its binding site is called CRE CR is reviewed in Saier, M.H., et al, 1996 (97086502) and Hueck, C.J. and Hillen, W., 1995 (95302950) it binds to fructose-1,6-bisphosphate and HPr |
| Link to | Phylogenetic profile , Weight matrix & Motif alignment |
| Regulated gene |
Operon | Sigma | Regulation | Absolute position | Location | Binding seq.(cis-element) | Exp. | Reference | Year |
|---|---|---|---|---|---|---|---|---|---|
| ackA | ND | ND | Positive | 3015538..3015552 | -124:-110 | TGTAAGCGTTCATCA |
DB DP | Grundy FJ, et al. | 1993 |
| ackA | ND | ND | Positive | 3015469..3015502 | -74:-41 | GACTTCTTATTGTAAGCGTTATCAATACGCAAGT |
DB DP | Grundy FJ, et al. | 1993 |
| acoA | ND | ND | Negative | 878767..878789 | ND | AAAATGTAAGCGTTTGCTTTTTC |
beta-gal | Miwa Y et al. | 2000 |
| acoR | ND | ND | Negative | 883022..883047 | -72:-46 | ATTGTTGAAAGCGCTTTATTTTTCCC |
FT | Ali, N. O., et al. | 2001 |
| acsA | ND | ND | Negative | 3038953..3038966 | +38:+51 | TGAAAGCGTTACCA |
DB SDM | Grundy FJ, et al. | 1994 |
| acuA | acuA-acuB-acuC | ND | Negative | 3039060..3039073 | -33:-20 | TGAAAACGCTTTAT |
DB SDM | Grundy FJ, et al. | 1994 |
| alsS | alsS-alsD | ND | Positive? | ND | ND | ND |
DB | Renna MC, et al. | 1993 |
| amyE | ND | ND | Negative | 327041..327064 | -7:+17 | TAAATGTAAGCGTTAACAAAATTC |
GS FT | Kim JH, et al. | 1995 |
| araA | araA-araB-araD-araL-araM-araN-araP-araQ-abfA | ND | Negative | 2947963..2947996 | +50:+83 | CTTTTGTATTTGAAAGCGTTTTATTTTATGAGAA |
beta-gal, Northern blot | Inacio, J. M., et al. | 2003 |
| araB | ND | ND | Negative | 2945742..2945764 | ND | TCAATGAAAACGATTACAAAGGA |
beta-gal | Miwa Y et al. | 2000 |
| araE | ND | ND | Negative | 3484521..3484534 | +67:+80 | TGAAAACGCTTTAC |
beta-gal, Northern blot | Inacio, J. M., et al. | 2003 |
| bglP | bglPH;aryl-beta-glucoside utilization | ND | Negative | 4034826..4034881 | -47:+9 | AAAATGAAAGCGTTGACATCTCACGAATCTAGTGCTAAAGTATACCT ACAAACAAA |
RO DP | Kruger S, et al. | 1996 |
| bglS | beta-glucanase | ND | Negative | 4011608..4011621 | ND | AGAAAACGCTTTCA |
SDM DB | Kruger S, et al. | 1993 |
| ccpC | ND | ND | ND | 1485238..1485259 | ND | GAAAAAAGAAAGCGCATACATA |
GS, FT | Kim, H. J., et al. | 2002 |
| citM | ND | ND | Negative | 833685..833707 | ND | AAAATGTAAGCGGATTCATTTAA |
beta-gal | Miwa Y et al. | 2000 |
| citZ | citZC | ND | Negative | 2981406..2981423 | +80:+97 | AATGTAAGCATTTTCTTT |
PF, GS, FT | Kim, H. J., et al. | 2003 |
| dra | dra-nupC-pdp operon | ND | Negative | 4051238..4051260 | ND | GCTTTGAAACCGCATACACAAAA |
beta-gal | Miwa Y et al. | 2000 |
| galT | ND | ND | Negative | 3919425..3919447 | ND | CGAATGGAAGCGGATACAGATAC |
beta-gal | Miwa Y et al. | 2000 |
| glpF | glpFK | ND | Negative | 1001650..1001668 | ND | GATTGACACCGCTTTCATG |
beta-gal, FT | Darbon, E., et al. | 2002 |
| gntR | gntRKPZ | ND | Negative | 4112544..4112566 | ND | TGATTGAAAGCGGTACCATTTTA |
beta-gal | Miwa Y et al. | 2000 |
| gntR | gntRKPZ | ND | Negative | 4112548..4112561 | +142:+155 | TGAAAGCGGTACCA |
SDM S1 HB | Miwa Y et al. | 1993 |
| hutP | hutPHUIGM operon;hutO-CR1 | ND | Negative | 4040470..4040483 | +2:+15 | GTTAATAGTTATCA |
SDM DP | Wray LV Jr, et al. | 1994 |
| hutP | hutPHUIGM operon;hutO-CR1 | ND | Negative | 4040671..4040684 | +203:+216 | TGAAACCGCTTCCA |
SDM DP | Wray LV Jr, et al. | 1994 |
| iolB | ND | ND | Negative | 4081178..4081200 | ND | GAAATGAAAACGTTGTCATCGTT |
beta-gal | Miwa Y et al. | 2000 |
| kdgA | ND | ND | Negative | 2322423..2322445 | ND | ATTATGGAAGCGCTGACATTCGG |
beta-gal | Miwa Y et al. | 2000 |
| lcfA | ND | ND | Negative | 2918966..2918988 | ND | AAAATGAAAACGTTATCAATAGT |
beta-gal | Miwa Y et al. | 2000 |
| levD | levDEFG-sacC operon | SigL | Negative | 2762125..2762139 | -50:-36 | TGAAAACGCTTAACA |
SDM DB | Martin-Verstraete I, et al. | 1995 |
| licB | licB-licC-licA-licH | ND | Negative | ND | ND | ND |
beta-gal | Tobisch, S., et al. | 1999 |
| licB | licB-licC-licA-licH | ND | Negative | 3960958..3960971 | -29:-16 | TGAAAGCGATTTCA |
HM | Tobisch S, et al. | 1997 |
| malA | glvA-glvR-glvC | ND | Negative | 889324..889350 | -7:+10 | TGGAATTGTAAACGTTATCAAGGAGGT |
beta-gal, PE, mutation of cis-elenent | Yamamoto, H., et al. | 2001 |
| mmgA | mmgABCDE | SigE | Negative | 2513250..2513263 | +15:+28 | TGTAAGCGCTGTCT |
SDM DB | Bryan EM, et al. | 1996 |
| mmsA | iolABCDEFGHIJ | ND | Negative | 4083484..4083511 | +83:+110 | TTTTTGAAAGCGTTTAATTCTTGGCTTG |
DP, base substitution analysis | Miwa Y et al. | 2000 |
| msmX | ND | ND | Negative | 3984265..3984287 | ND | TATAAGAAAGCGTTTACAATAAC |
beta-gal | Miwa Y et al. | 2000 |
| pta | ND | SigA | Negative | 3865420..3865454 | -70:-35 | TTTTTTATGAAAGCGCTATAATGAAAGTTGGCTGT |
FT | Presecan-Siedel, E., et al. | 1999 |
| pta | ND | SigA | Negative | 3865357..3865396 | -11:+29 | ATGCTAGTAAAAGAAAGCGTTTTTGTAACTTTTTGAGGAG |
FT | Presecan-Siedel, E., et al. | 1999 |
| rbsR | rbsR-rbsK-rbsD-rbsA-rbsC-rbsB | SigA | Negative | 3700395..3700428 | -11:+23 | AATCTATCTATGTAAACGGTTACATAAACAAGGA |
PE | Woodson K, et al. | 1994 |
| treP | ND | ND | Negative | 850018..850040 | ND | GCTGTGAAAACGCTTGCAGATAT |
beta-gal | Miwa Y et al. | 2000 |
| xylA | xylA-xylB | ND | Negative | 1891151..1891164 | +134:+147 | TGGAAGCGCAAACA |
SDM | Kraus A, et al. | 1994 |
| xynP | xynP-xynB | ND | Negative | 1886244..1886265 | ND | AGTTTGTTTGATC-AACAAACTA |
DB HB HM | Lindner C, et al. | 1994 |
| ydbH | ND | ND | Negative | 499660..499682 | ND | TGTATGAAAACGCTATCATTCTA |
beta-gal | Miwa Y et al. | 2000 |
| ydhO | ND | ND | Negative | 627486..627508 | ND | GACTTGGAAGCGGTATCATTCCA |
beta-gal | Miwa Y et al. | 2000 |
| yjmA | yjmABCDEFGHIJ(No experimantal validation) | ND | Negative | 1300933..1300955 | ND | CAAATGAAAGCGTTATCAAATGT |
beta-gal | Miwa Y et al. | 2000 |
| yobO | ND | ND | Negative | 2076591..2076613 | ND | TTAATGTAAGCGGATTCACAGCG |
beta-gal | Miwa Y et al. | 2000 |
| yxjC | ND | ND | Negative | 4003174..4003196 | ND | TTTTTGTAAACGCTTTCTAGTTC |
beta-gal | Miwa Y et al. | 2000 |
| yxkJ | ND | ND | Negative | 3978796..3978818 | ND | CAATTGCAAACGGATACAATTCA |
beta-gal | Miwa Y et al. | 2000 |