Regulated Operon: uxaC-yjmBCD-uxuA-yjmF-exuTR-uxaBA

Genes
Genes Synonyms Direction Genome position Function COG ID Genus clusters
uxaC yjmA + 1299760..1301181 glucuronate isomerase COG1904  
yjmB
+ 1301249..1302628
COG2211  
yjmC
+ 1302733..1303746
COG2055  
yjmD
+ 1303752..1304771
COG1063  
uxuA yjmE + 1304796..1305875 D-mannonate hydrolase COG1312  
yjmF
+ 1305872..1306708
COG1028  
exuT yjmG + 1306756..1308024 hexuronate transporter COG0477  
exuR yjmH + 1308112..1309113 transcriptional regulator (LacI family) COG1609  
uxaB yjmI + 1309190..1310632 tagaturonate reductase (altronate oxidoreductase) COG0246  
uxaA yjmJ + 1310629..1312122 altronate hydrolase COG2721  

Operon evidence: Genome analysis
Reference: Mekjian KR, et al. (1999), Rivolta C, et al. (1998)
Comments:

Promoters

Binding
factor		 Regulation Location Absolute position Binding seq.(cis-element) Experimental evidence
CcpA Negative +218:+240 1300933..1300955 CAAATGAAAGCGTTATCAAATGT Miwa Y, et al. (2000): RG
ExuR Negative -5:+39 1299702..1299745 AAAACAAATCAAAATGTTAACGTTAACATTTTGAAATAGAATGA Mekjian KR, et al. (1999): DB RG SDM
SigA Promoter -39:+9 1299668..1299715 GAGATTGATCCCAAAGGAATATAAAGGTAAAATAAAAACAAATCAAAA Mekjian KR, et al. (1999): PE SDM RG
SigE Promoter -46:+3 1302632..1302680 TATAATATAAAGAATATTTAAAATAATTTGTAAATAAAATGTGTTTGTA Mekjian KR, et al. (1999): PE RG

Terminator

Terminator sequence Absolute position Position from stop codon Free energy
[kcal/mol]		 Downstream of
GAAAAGGCTATCCTTCAAGCGGATAGCCTTCTTCATTAAATCA
     >>>>>>>>       <<<<<<<<
1312131..1312153
9..31
-14.6
 uxaA

Overview



Upper Region
Copyright: Human Genome Center, Inst. Med. Sci., Univ. Tokyo; 1999-2006
Contact: Kenta Nakai