Transcription factor: CcpA

Factor type	LacI family
SWISS-PROT	P25144
SubtiList	BG10376
Consensus seq.	WTGNAANCGNWNNCW
Comment	also called AlsA; common repressor in catabolite repression (CR) but may act as a positive regulator of genes involved in excretion of excess carbon; its binding site is called CRE; it binds to fructose-1,6-bisphosphate and HPr
Link to	Phylogenetic profile, Weight matrix, Motif alignment & Similar conserved hexameric motifs

Operon	Regulated Gene	Sigma	Regulation	Absolute position	Location	Binding seq.(cis-element)	Experimental evidence
ackA	ackA	SigA	Positive	`3015538..3015552`	`-124:-110`	TGTAAGCGTTCATCA	Grundy FJ, et al. (1993): DB DP
ackA	ackA	SigA	Positive	`3015469..3015502`	`-74:-41`	GACTTCTTATTGTAAGCGTTATCAATACGCAAGT	Grundy FJ, et al. (1993): DB DP
acoABCL	acoA	SigL	Negative	`878767..878789`	`+459:+481`	AAAATGTAAGCGTTTGCTTTTTC	Miwa Y, et al. (2000): RG
acoR-sspH	acoR	None	Negative	`883022..883047`	None	ATTGTTGAAAGCGCTTTATTTTTCCC	Ali NO, et al. (2001): FT
acsA	acsA	SigA	Negative	`3038953..3038966`	`+38:+51`	TGAAAGCGTTACCA	Grundy FJ, et al. (1994): DB SDM
acuABC	acuA	SigA	Negative	`3039060..3039073`	`-33:-20`	TGAAAACGCTTTAT	Grundy FJ, et al. (1994): DB SDM
alsSD	alsS	SigA	Positive	ND	ND	ND	Renna MC, et al. (1993): DB
amyE	amyE	SigA	Negative	`327041..327064`	`-7:+17`	TAAATGTAAGCGTTAACAAAATTC	Kim JH, et al. (1995): GS FT Kim JH, et al. (2005): PE FT
araABDLMNPQ-abfA	araA	SigA	Negative	`2947963..2947996`	`+50:+83`	CTTTTGTATTTGAAAGCGTTTTATTTTATGAGAA	Inacio JM, et al. (2003): RG NB
araABDLMNPQ-abfA	araB	None	Negative	`2945742..2945764`	None	TCAATGAAAACGATTACAAAGGA	Miwa Y, et al. (2000): RG
araE	araE	SigA	Negative	`3484521..3484534`	`+67:+80`	TGAAAACGCTTTAC	Inacio JM, et al. (2003): RG NB
bglPH-yxiE	bglP	SigA	Negative	`4034832..4034881`	`-47:+3`	AAAATGAAAGCGTTGACATCTCACGAATCTAGTGCTAAAGTATACCTACA	Kruger S, et al. (1996): RO DP
licT-bglS	bglS	SigA	Negative	`4011608..4011621`	None	AGAAAACGCTTTCA	Kruger S, et al. (1993): SDM DB
ykuJK-ykzF-ykuL-ccpC	ccpC	SigA	Negative	`1485238..1485259`	`-81:-60`	GAAAAAAGAAAGCGCATACATA	Kim HJ, et al. (2002): GS FT
citM-yflN	citM	SigA	Negative	`833685..833707`	`+37:+59`	AAAATGTAAGCGGATTCATTTAA	Miwa Y, et al. (2000): RG
citZ-icd-mdh	citZ	SigA	Negative	`2981406..2981423`	`+80:+97`	AATGTAAGCATTTTCTTT	Kim HJ, et al. (2002): PE DB RG SDM GS
cydABCD	cydA	SigA	Negative	`3978417..3978446`	`-8:-37`	CTTTATTTTTGAAATGAATCGTTGTAAAGT	Puri-Taneja A, et al. (2007): RG FT
dctSRP	dctP	SigA	Negative	`499642..499691`	`-43:+7`	TCATAAACTTCCCCAGACTGTATGAAAACGCTATCATTCTAGTAAGAAAG	Miwa Y, et al. (2000): RG Asai K, et al. (2000): DP RG DB
deoR-dra-nupC-pdp	dra	SigA	Negative	`4051238..4051260`	`+62:+84`	GCTTTGAAACCGCATACACAAAA	Miwa Y, et al. (2000): RG
galKT	galT	None	Negative	`3919425..3919447`	None	CGAATGGAAGCGGATACAGATAC	Miwa Y, et al. (2000): RG
glpFK	glpF	SigA	Negative	`1001650..1001668`	`-37:-19`	GATTGACACCGCTTTCATG	Darbon E, et al. (2002): RG FT
gntRKPZ	gntR	SigA	Negative	`4112544..4112566`	`+138:+160`	TGATTGAAAGCGGTACCATTTTA	Miwa Y, et al. (1993): SDM S1 HB Chauvaux S, et al. (1998): DB RG Miwa Y, et al. (2000): RG Kim JH, et al. (2005): FT
hut	hutP	SigA	Negative	`4040470..4040483`	`+2:+15`	GTTAATAGTTATCA	Wray LV Jr, et al. (1994): SDM DP
hut	hutP	SigA	Negative	`4040671..4040684`	`+203:+216`	TGAAACCGCTTCCA	Wray LV Jr, et al. (1994): SDM DP
ilvBHC-leuABCD	ilvB	SigA	Positive	`2896571..2896624`	`-106:-53`	TGTACCAATAATGAAAGCGTATACAATATAGATTGATTAATCAAAATTGTCTAA	Tojo S, et al. (2005): FT Shivers RP, et al. (2005): FT
kdgRKAT	kdgA	None	Negative	`2322423..2322445`	None	ATTATGGAAGCGCTGACATTCGG	Miwa Y, et al. (2000): RG
lcfA-ysiAB-etfBA	lcfA	None	Negative	`2918966..2918988`	None	AAAATGAAAACGTTATCAATAGT	Miwa Y, et al. (2000): RG
levDEFG-sacC	levD	SigL	Negative	`2762125..2762139`	`-50:-36`	TGAAAACGCTTAACA	Martin-Verstraete I, et al. (1995): SDM DB
licBCAH	licB	SigA	Negative	`3960937..3960982`	`-40:+6`	CTGAGTGTTTATGAAAGCGATTTCATAATATGATGATAGCAACAGC	Tobisch S, et al. (1999): RG Tobisch S, et al. (1997): HM
malA-yfiA-malP	malA	SigA	Negative	`889324..889350`	`-7:+10`	TGGAATTGTAAACGTTATCAAGGAGGT	Yamamoto H, et al. (2001): RG PE SDM
mmgABCDE-yqiQ	mmgA	SigE	Negative	`2513250..2513263`	`+15:+28`	TGTAAGCGCTGTCT	Bryan EM, et al. (1996): SDM DB
mmsA-iolBCDEF-idh-iolHI-fbaB	mmsA	SigA	Negative	`4083484..4083511`	`+83:+110`	TTTTTGAAAGCGTTTAATTCTTGGCTTG	Miwa Y, et al. (2000): DP SDM
mmsA-iolBCDEF-idh-iolHI-fbaB	iolB	None	Negative	`4081178..4081200`	None	GAAATGAAAACGTTGTCATCGTT	Miwa Y, et al. (2000): RG
yxkF-msmX	msmX	None	Negative	`3984265..3984287`	None	TATAAGAAAGCGTTTACAATAAC	Miwa Y, et al. (2000): RG
phoPR	phoP	SigA	Negative	`2977703..2977732`	`+5:+34`	TTTACTATAAATGAAAGCGCTATCATAAAC	Puri-Taneja A, et al. (2005): DB RG SDM GS FT
pta	pta	SigA	Negative	`3865420..3865454`	`-70:-35`	TTTTTTATGAAAGCGCTATAATGAAAGTTGGCTGT	Presecan-Siedel E, et al. (1999): FT
pta	pta	SigA	Negative	`3865357..3865396`	`-11:+29`	ATGCTAGTAAAAGAAAGCGTTTTTGTAACTTTTTGAGGAG	Presecan-Siedel E, et al. (1999): FT
rbsRKDACB	rbsR	SigA	Negative	`3700395..3700428`	`-11:+23`	AATCTATCTATGTAAACGGTTACATAAACAAGGA	Woodson K, et al. (1994): PE
sigL	sigL	None	Negative	`3512248..3512281`	None	AAAAAATGGAAAACGCTTTCAGTAGAGACGGGAA	Choi SK, et al. (2005): SDM
trePAR	treP	SigA	Negative	`850018..850040`	`+362:+384`	GCTGTGAAAACGCTTGCAGATAT	Miwa Y, et al. (2000): RG
uxaC-yjmBCD-uxuA-yjmF-exuTR-uxaBA	uxaC	SigA	Negative	`1300933..1300955`	`+218:+240`	CAAATGAAAGCGTTATCAAATGT	Miwa Y, et al. (2000): RG
xylAB	xylA	SigA	Negative	`1891143..1891172`	`+132:+161`	AACTATTTTGGAAGCGCAAACAAAGTGGTT	Gartner D, et al. (1988): RG Jacob S, et al. (1991): RG DP Kraus A, et al. (1994): SDM DP RG Chauvaux S, et al. (1998): DB RG Kim JH, et al. (2005): PE FT
xynPB	xynP	SigA	Negative	`1886457..1886480`	`+219:+242`	TGTTTTGAAAGCGCTTTTATAAAA	Lindner C, et al. (1994): DB HB HM RG Galinier A, et al. (1999): DP RG FT
ydhO	ydhO	None	Negative	`627486..627508`	None	GACTTGGAAGCGGTATCATTCCA	Miwa Y, et al. (2000): RG
yobO	yobO	None	Negative	`2076591..2076613`	None	TTAATGTAAGCGGATTCACAGCG	Miwa Y, et al. (2000): RG
yxjC-scoAB-yxjF	yxjC	SigE	Negative	`4003174..4003196`	`+32:+54`	TTTTTGTAAACGCTTTCTAGTTC	Miwa Y, et al. (2000): RG
yxkJ	yxkJ	None	Negative	`3978796..3978818`	None	CAATTGCAAACGGATACAATTCA	Miwa Y, et al. (2000): RG