Transcription factor: DegU

Factor type	LuxR/UhpA family
SWISS-PROT	ND
SubtiList	ND
Consensus seq.	TAAAT
Comment	pleiotropic regulator involved in various post-exponential phase responses; makes a two component system with DegS kinase
Link to	Phylogenetic profile, Weight matrix & Motif alignment

Operon	Regulated Gene	Sigma	Regulation	Absolute position	Location	Binding seq.(cis-element)	Experimental evidence
amyE	amyE	SigA	Positive	ND	ND	ND	Ayusawa D, et al. (1975): DB, amylase activity Yoneda Y & Maruo B (1975): DB, amylase activity Steinmetz M, et al. (1976): DB, amylase activity Lepesant JA, et al. (1976): Microbiology-1976, edited by David Schlessinger; pages 58-69: DB, amylase activity
aprE	aprE	SigA	Positive	`1105645..1105704`	`-83:-24`	GATATACCTAAATAGAGATAAAATCATCTCAAAAAAATGGGTCTACTAAAATATTATTCC	Kunst F, et al. (1974): serine protease activity; DB Ayusawa D, et al. (1975): protease activity; DB Yoneda Y & Maruo B (1975): serine protease activity; DB Lepesant JA, et al. (1976): Microbiology-1976, edited by David Schlessinger; pages 58-69: DB, serine protease activity Ferrari E, et al. (1986): DB RG Tanaka T & Kawata M (1988): serine protease activity; DB Henner DJ, et al. (1988): Genetics and biotechnology of Bacilli, vol.2 pp.3-9: DP RG Mukai K, et al. (1992): DP DB OV RG Ogura M, et al. (2003): RG DB GS Shimane K & Ogura M (2004): SDM DB RG Kobayashi K, et al. (2010): AR HB DB GS
licT-bglS	bglS	SigA	Positive	ND	ND	ND	Aymerich S et al. (1986): DB, glucanase activity
comK	comK	SigA	Positive	`1116971..1117005`	`-102:-73`	TTATTACTAGTCATTTAGTACCATTAAATATCATT	Hahn J, et al. (1994): DB Van Sinderen D & Venema G (1994): RG DB; Western blot Ogura M, et al. (1996): DB RG Hamoen LW, et al. (2000): GS FT Shimane K & Ogura M (2004): SDM RG
degQ	degQ	SigA	Positive	ND	ND	ND	Msadek T, et al. (1990): DB RG Msadek T, et al. (1991): DP DB RG
ispA	ispA	SigA	Positive	ND	ND	ND	Ruppen ME, et al. (1988): DB RG, protease activity
nprE	nprE	SigA	Positive	ND	ND	ND	Kunst F, et al. (1974): neutral protease activity; DB Ayusawa D, et al. (1975): protease activity; DB Yoneda Y & Maruo B (1975): neutral protease activity; DB Lepesant JA, et al. (1976): Microbiology-1976, edited by David Schlessinger; pages 58-69: DB, metal protease activity Tanaka T & Kawata M (1988): neutral protease activity; DB
sacB-yveBA	sacB	SigA	Positive	`3535696..3535721`	`-110:-85`	GATAGATTTTTTAGTTCTTTAGGCCC	Kunst F, et al. (1974): levansucrase activity; DB Steinmetz M, et al. (1976): DB, levansucrase activity Lepesant JA, et al. (1976): Microbiology-1976, edited by David Schlessinger; pages 58-69: DB, levansucrase activity Chambert R & Petit-Glatron MF (1984): levansucrase activity; SDS-PAGE DB Aymerich S et al. (1986): RG DB dot-blot Shimotsu H & Henner DJ (1986): S1 RG DB Klier A et al. (1987): levansucrase activity, DB DP Henner DJ, et al. (1988): Genetics and biotechnology of Bacilli, vol.2 pp.3-9: DP RG Tsukahara K, et al. (2008): FT HB SDM
sacXY	sacX	SigA	Positive	`3941835..3941891`	`-112:-56`	GTCTTAAAGGTTTTTTTCATTCTAAGAACACCACACACAACCTTTTTCCCATCCATT	Crutz AM & Steinmetz M (1992): DB RG DP
sipS	sipS	None	Positive	`2433527..2433547`	`-648:-628`	GATGTAATGAAAAGGAGATCG	Bolhuis A, et al. (1996): DB OV RG NB Tjalsma H, et al. (1998): OV RG
sipT	sipT	None	Positive	`1511245..1511266`	None	TTTTTTATGATAAAGTAAAAGA	Tjalsma H, et al. (1998): OV RG NB
wapA-yxxG	wapA	SigA	Negative	`4030602..4030625`	`-42:-19`	AAAAATATTGTAATGATATTTCAG	Dartois V, et al. (1998): DB RG DP PE SDM
wapA-yxxG	wapA	SigA	Negative	`4030563..4030579`	`+5:+21`	ATATTACTTTTATTACA	Dartois V, et al. (1998): DB RG DP PE SDM
yxjJI	yxjJ	None	Negative	ND	ND	ND	Dartois V, et al. (1998): Unpublished data
ywsC-ywtABC	ywsC	None	Positive	`3700687..3700711`	`-47:-23`	ACATAATGCCGATTGAGAATTCATA	Ohsawa T, et al. (2009): GS FT
ywsC-ywtABC	ywsC	None	Positive	`3700687..3700711`	`-47:-23`	ACATAATGCCGATTGAGAATTCATA	Ohsawa T, et al. (2009): GS FT
degSU	degU	sigA	Positive	`3645305..3645385`	`-72:+7`	TCTTTGACTATGATTTGTAAAATAGAGCCAAAAGGCATATTGACCGAATGCTAGAGTATATAGAACAATAATACAAGGAGG	Yasumura A, et al. (2008): RG NB DP DB OV Ogura M, (2010): FT GS SDM Kobayashi K, et al. (2010): AR HB DB GS
degSU	degU	sigA	Positive	`3645386..3645417`	`-106:-75`	GGGACATTTATTATGATTAAGGTTCCGTTATC	Ogura M, et al (2010): FT GS SDM Kobayashi K, et al. (2010): AR HB DB GS
ycdA	ycdA	SigA	Positive	`300723..300813`	`-130:-40`	CCAACTAATCAAAAAGTAATAGTCTAAAATACACAGTTTTCTGAGTTTACCAGTTTTACCAGAACATTTTTCACCAAAAATAGGATGATGA	Kobayashi K, et al. (2010): AR HB DB GS Ogura M, et al. (2012): GS FT DP
yukEDCB-yueB	yukE	SigA	Positive	ND	ND	ND	Kobayashi K, et al. (2010): AR HB DB GS
fla-che	flgB	SigA	Negative	ND	ND	ND	Amati G, et al. (2004): RG GS
fla-che	flgB	SigA	Positive	`1691108..1691148`	`-106:-66`	CTAACAATCTAGGACTTTATACCTAGTTGCAAAATAGATAA	Tsukahara K, et al (2008): FT Kobayashi K, et al. (2010): AR HB DB GS
fla-che	flgB		Positive	`1691328..1691356`	`+115:+145`	AGCGGATATTAAGCAAAAAGTCATAACTA	Tsukahara K, et al (2008): FT Kobayashi K, et al. (2010): AR HB DB GS
bpr	bpr	SigA	Positive	`1599043..1599138`	`-155:-60`	TTATAAAGTCTTTTTCCCTATTGCTTCCTTCGCTTAGTAACAAAACAGATAATTAGACCCATTTATTTTTGTGACATTTTTATCATTTTCATATAT	Tsukahara K, et al (2008): FT RG SDM