Transcription factor: ComK

Factor type	Unique (CTF)
SWISS-PROT	P40396
SubtiList	BG11059
Consensus seq.	AAAANNNNNTTTT
Comment	Positive autoregulatory gene occupying a central position in the competence-signal-transduction network; CTF = competence transcription factor. Typically, more than one ComK binding site is found in each promoter, with distances of 8, 18, or 31 basepairs between them.
Link to	Phylogenetic profile, Weight matrix, Motif alignment & Similar conserved hexameric motifs

Operon	Regulated Gene	Sigma	Regulation	Absolute position	Location	Binding seq.(cis-element)	Experimental evidence
addBA	addB	SigA	Positive	`1135507..1135530`	`-90:-67`	TGCGGAGATAATCAGCTTTTTATA	Haijema BJ, et al. (1995): DB OV RG DP GS Hamoen LW, et al. (1998): FT
addBA	addB	SigA	Positive	`1135530..1135556`	`-67:-41`	ATGTGAAAAGGCCGTTTTTACCAATAG	Haijema BJ, et al. (1995): DB OV RG DP GS Hamoen LW, et al. (1998): FT
bdbDC	bdbD	SigE	Positive	ND	ND	ND	Meima R, et al. (2002): RG
comC	comC	SigA	Positive	`2864491..2864520`	`-94:-65`	AGAATCAAAAAAAGATTCTGCCGTTTTTTT	Guillen N, et al. (1989): DB RG Van Sinderen D, et al. (1994): DB RG Van Sinderen D, et al. (1995): GS Hamoen LW, et al. (1998): FT
comC	comC	SigA	Positive	`2864462..2864491`	`-65:-36`	TCATGTGTAAAATTGAATATTCCCAATTGG	Guillen N, et al. (1989): DB RG Van Sinderen D, et al. (1994): DB RG Van Sinderen D, et al. (1995): GS Hamoen LW, et al. (1998): FT
comEABC	comEA	SigA	Positive	`2641316..2641340`	`-82:-58`	AAACCATCGTTTCCTAAAACGATGG	Guillen N, et al. (1989): DB RG Van Sinderen D, et al. (1994): DB RG Van Sinderen D, et al. (1995): GS Hamoen LW, et al. (1998): FT
comEABC	comEA	SigA	Positive	`2641288..2641316`	`-58:-32`	GTTTTTTAAAATGCTTTTTTATGCTTTTG	Guillen N, et al. (1989): DB RG Van Sinderen D, et al. (1994): DB RG Van Sinderen D, et al. (1995): GS Hamoen LW, et al. (1998): FT
comFABC-yvyF-flgM-yvyG-flgKL	comFA	SigA	Positive	`3642668..3642697`	`-92:-63`	ATAAGGCCAAATCTCCGTTTTTAGAGCGGA	Londono-Vallejo JA, et al. (1993): DB RG Van Sinderen D, et al. (1995): GS RG OV Hamoen LW, et al. (1998): FT Liu J & Zuber P (1998): DB Ogura M, et al. (2002): AR RG DB
comFABC-yvyF-flgM-yvyG-flgKL	comFA	SigA	Positive	`3642638..3642668`	`-63:-33`	AGATTTTTTTATATTCTTATTTTAATAGTTG	Londono-Vallejo JA, et al. (1993): DB RG Van Sinderen D, et al. (1995): GS RG OV Hamoen LW, et al. (1998): FT Liu J & Zuber P (1998): DB Ogura M, et al. (2002): AR RG DB
comGABCDEFG-yqzE	comGA	SigA	Positive	`2559398..2559433`	`-104:-69`	TCTTTTTTCTTGCCAGAAAGAATTGGTTTTTCAGCA	Guillen N, et al. (1989): DB RG Roggiani M, et al. (1990): RG DB Kong L, et al. (1993): RG DB Kong L & Dubnau D (1994): RG DB Van Sinderen D, et al. (1994): DB RG Van Sinderen D, et al. (1995): GS RG OV Msadek T, et al. (1995): Two-Component Signal Transduction, pp. 447-471: DB RG Hahn J, et al. (1996): DB OV RG Hamoen LW, et al. (1998): FT Berka RM, et al. (2002): AR HM
comGABCDEFG-yqzE	comGA	SigA	Positive	`2559361..2559398`	`-69:-32`	ATATAACATCTCACAAAATCACGTTTTCCCTGTTTGAT	Guillen N, et al. (1989): DB RG Roggiani M, et al. (1990): RG DB Kong L, et al. (1993): RG DB Kong L & Dubnau D (1994): RG DB Van Sinderen D, et al. (1994): DB RG Van Sinderen D, et al. (1995): GS RG OV Msadek T, et al. (1995): Two-Component Signal Transduction, pp. 447-471: DB RG Hahn J, et al. (1996): DB OV RG Hamoen LW, et al. (1998): FT Berka RM, et al. (2002): AR HM
comK	comK	SigA	Positive	`1116259..1116294`	`-118:-83`	TGAAAGTAAAATCGGTTTATTACTAGTCATTTAGTA	Van Sinderen D & Venema G (1994): RG OV DB; Western blot Van Sinderen D, et al. (1995): GS Hamoen LW, et al. (1998): FT Berka RM, et al. (2002): AR HM
comK	comK	SigA	Positive	`1116294..1116322`	`-83:-55`	ACCATTAAATATCATTAAAAGATGATTTT	Van Sinderen D & Venema G (1994): RG OV DB; Western blot Van Sinderen D, et al. (1995): GS Hamoen LW, et al. (1998): FT Berka RM, et al. (2002): AR HM
cspB	cspB	SigA	Unknown	`983511..983544`	Downstream of cspB	AAAAAGCTGTTTTGCATAAGCAAAACAGCTTTTT	Hamoen LW, et al. (1998): GS DP
degR	degR	SigD	Negative	ND	ND	ND	Ogura M & Tanaka T (1996): DB RG Ogura M, et al. (1997): DB DP
nucA-nin	nucA	None	Positive	`372269..372298`	None	CGTATTTTGCTGAAAACAAATATTTCGATC	Van Sinderen D, et al. (1995): RG DB GS
nucA-nin	nucA	None	Positive	`372245..372269`	None	CTGCTAAAATTACGATTTCTGCAAT	Van Sinderen D, et al. (1995): RG DB GS
rapH-phrH	rapH	SigA	Positive	`750187..750220`	`-75:-42`	AAAAAACAAATTGACAGGATGAAAAAACAATTTC	Ogura M, et al. (2002): AR RG HM DB Hayashi K, et al. (2006): RG DB
recA	recA	SigA	Positive	`1763735..1763755`	`-150:-130`	GCAAAAATAATATTTTCAGCA	Hamoen LW, et al. (2001): FT GS Haijema BJ, et al. (1996): FT GS RG DB DP Cheo DL, et al. (1992): DP RG
recA	recA	SigA	Positive	`1763765..1763790`	`-120:-95`	CCTAAGAAAACATGATTTCTCTGATA	Hamoen LW, et al. (2001): FT GS Haijema BJ, et al. (1996): FT GS RG DB DP Cheo DL, et al. (1992): DP RG
recA	recA	SigA	Positive	`1763790..1763810`	`-95:-75`	ACATTATGATATTTTGATAGG	Hamoen LW, et al. (2001): FT GS Haijema BJ, et al. (1996): FT GS RG DB DP Cheo DL, et al. (1992): DP RG
recA	recA	SigA	Positive	`1763822..1763842`	`-65:-35`	GAAAAAATCCGAATATGCGTT	Hamoen LW, et al. (2001): FT GS Haijema BJ, et al. (1996): FT GS RG DB DP Cheo DL, et al. (1992): DP RG
rok	rok	None	Negative	`1492948..1492968`	None	TGAAAAATAAAACATTTTCAG	Hoa TT, et al. (2002): GS RG DB
rok	rok	None	Negative	`1492968..1492984`	None	GAAAATAAGGAATTTTT	Hoa TT, et al. (2002): GS RG DB
sbcD-yirY-yisB	sbcD	None	Positive	ND	ND	ND	Ogura M, et al. (2002): AR RG DB
smf	smf	None	Positive	`1681787..1681803`	None	AAGAACTTGTTCGAAAC	Ogura M, et al. (2002): AR RG HM DB
smf	smf	None	Positive	`1681803..1681820`	None	CTTGTAAAACGCATTAAT	Ogura M, et al. (2002): AR RG HM DB
thdF-gidAB-yyaA	thdF	None	Positive	`4211972..4211993`	None	CAAACTATGTTATCTTTTAGTT	Ogura M, et al. (2002): AR RG HM DB
thdF-gidAB-yyaA	thdF	None	Positive	`4211950..4211972`	None	TTTGGCATAATAAAAATTTTTTT	Ogura M, et al. (2002): AR RG HM DB
ybdK	ybdK	None	Positive	`221708..221725`	None	AAAATTTTCTTTTATTTA	Ogura M, et al. (2002): AR RG HM DB
ybdK	ybdK	None	Positive	`221746..221764`	None	CCTGACAAAGGAACATTTC	Ogura M, et al. (2002): AR RG HM DB
yhbIJ-yhcABCDEFGHI	yhcE	None	Positive	ND	ND	ND	Ogura M, et al. (2002): AR RG DB
yhbIJ-yhcABCDEFGHI	yhcF	None	Positive	ND	ND	ND	Ogura M, et al. (2002): AR RG DB
yhbIJ-yhcABCDEFGHI	yhcH	None	Positive	ND	ND	ND	Ogura M, et al. (2002): AR RG DB
yhjCB	yhjB	None	Positive	`1120241..1120262`	None	AAAATAAATTTATTTATAATTC	Ogura M, et al. (2002): AR RG HM DB
yhjCB	yhjB	None	Positive	`1120206..1120226`	None	CACTCCAAAAAATGACATGTG	Ogura M, et al. (2002): AR RG HM DB
yneAB-ynzC	yneA	None	Positive	ND	ND	ND	Ogura M, et al. (2002): AR RG DB
yneAB-ynzC	yneB	None	Positive	`1917796..1917818`	None	TAAACAAAAATGATTTTATTGAA	Ogura M, et al. (2002): AR RG HM DB
yneAB-ynzC	yneB	None	Positive	`1917827..1917849`	None	TGATAAAAATCAACTTCAAACCT	Ogura M, et al. (2002): AR RG HM DB
radC	radC	None	Positive	`2861985..2862007`	None	AAGACAGAAGTTGCGTTTTGGTC	Ogura M, et al. (2002): AR RG HM DB
radC	radC	None	Positive	`2861964..2861985`	None	CCCTCAGTGAAGAAGAGATTTG	Ogura M, et al. (2002): AR RG HM DB
yvrPON	yvrP	None	Positive	`3414440..3414459`	None	ATATGACTTGATTAAAAATG	Ogura M, et al. (2002): AR RG HM DB
yvrPON	yvrP	None	Positive	`3414403..3414423`	None	TGTATGAAAAAATCCCGGTTT	Ogura M, et al. (2002): AR RG HM DB
ywpH-glcR	ywpH	None	Positive	`3739714..3739737`	None	AAAAGTACATATTTCTTCAAAGGA	Ogura M, et al. (2002): AR RG HM DB
ywpH-glcR	ywpH	None	Positive	`3739694..3739714`	None	AAAAAAGCAAAAGATGTTTTT	Ogura M, et al. (2002): AR RG HM DB
yyaF-rpsF-ssb-rpsR	yyaF	None	Positive	`4200078..4200094`	None	ATCAAAGGGATTGGCAA	Ogura M, et al. (2002): AR RG HM DB
yyaF-rpsF-ssb-rpsR	yyaF	None	Positive	`4200061..4200078`	None	AGCTGAAAATGCTTTTTT	Ogura M, et al. (2002): AR RG HM DB